Characterization of posttranslational modification such as phosphorylation, glycosylation or disulphide bonds.Peptide mass fingerprinting – identification of proteins from gel or solution including larger protein mixtures by using MALDI or ESI.Protein molecular weight determination by ultra-high resolution FT-ICR mass spectrometer with sequence confirmation by Top-down approach using different fragmentation techniques (collision induced dissociation, electron transfer/capture dissociation).This equipment allows to provide the following services: Further possibilities include peptide mass fingerprinting, detection of small molecule/metabolites, monitoring of protein structural changes and protein-protein interactions under physiological conditions by hydrogen-deuterium exchange, chemical cross-linking and covalent labelling.Īgilent Technologies 1200 HPLC system (usually coupled to the 15T-SolariX XR mass spectrometer) for the separation of complex peptide mixtures, proteins and metabolites.
This ultra-high resolution mass spectrometer is used mostly for the determination of the precise mass of biological macromolecules, and the characterization of their posttranslational modifications. The main focus of the services lies in monitoring of proteins structural changes and protein-protein interaction by chemical cross-linking and hydrogen-deuterium exchange.īruker Daltonics 15T-Solarix XR FT-ICR mass spectrometer, with electrospray and MALDI ion sources. The core facility Structural mass spectrometry provides analyses of hundreds of samples and supports many internal and external structural biology projects.
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Hundreds of samples are processed per year in the self-assisted mode or with full staff support.
The core facility devoted to diffraction analysis offers crystal quality screening, in situ crystal testing, single crystal data collection and processing, small angle X-ray scattering (SAXS) experiments with robotic sample loading and online UV-VIS spectrometry, and SAXS data processing.
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The core facility Crystallization of proteins and nucleic acids enables thousands of crystallization experiments using robotic or manual setup, automated monitoring of crystal growth, experiments at selected temperatures or under defined conditions, to prepare samples for further crystallographic studies. Our banquet hall has been closed permanently to rentals.The core facility Biophysical techniques enables assessment of the quality, stability and interaction properties of hundreds of biomolecular samples of many structural biology projects, be it regular checks, thorough analysis of properties or optimization of molecular constructs or handling protocols.ĬF Crystallization of Proteins and Nucleic Acids Please note: unvaccinated individuals must continue to wear masks while in parish buildings. Our Parish Center allows us to safely congregate and welcome parishioners and guests alike! Remember our Parish Center is accessible and has great parking. Concfession are heard on Saturdays from 3:30 p.m. and Sundays at 9:30 a.m.) remain at our Parish Center located at 1001 Main Street East (aka West Ridge Road and Route 20), Girard, PA 16417. Please join us to celebrate Mass in person. May the Lord’s every blessing be yours today and always! It’s a great community and a wonderful place to worship.Īs the People of God, we rejoice in doing our very best to live and love like Christ! We are committed to loving God, loving others, and making disciples.įounders, long-time parishioners, newcomers,Īnd those visiting the area are all welcome. John the Evangelist is a wonderful, welcoming Family of Faith located in Girard, Pennsylvania.
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